Company · CIK 1636282 # Spyre Therapeutics, Inc. | CIK | [1636282](https://www.sec.gov/cgi-bin/browse-edgar?action=getcompany&CIK=0001636282) (SEC EDGAR) | | --- | --- | | Industry (SIC) | 2834 — Pharmaceutical Preparations | | Incorporated in | DE | | Business address | MA | | Listed | SYRE (Nasdaq) | | First annual or quarterly report | 2016-05-19 | ## Offerings 13 registrations | Registration | Label and status | First filed | Last event | Filings | | --- | --- | --- | --- | --- | | 333-297063 | Shelf Effective | 2026-06-26 | 2026-10-06 | 3 | | 333-293600 | Shelf Effective | 2026-02-19 | 2026-04-16 | 4 | | 333-285341 | Shelf Effective | 2025-02-27 | 2026-03-04 | 5 | | 333-281975 | Shelf Effective | 2024-09-06 | 2025-03-13 | 5 | | 333-282252 | Shelf Effective | 2024-09-20 | 2024-10-02 | 2 | | 333-278810 | Registered company Effective | 2024-04-19 | 2024-04-29 | 2 | | 333-273769 | Shelf Effective | 2023-08-07 | 2024-04-01 | 5 | | 333-276251 | Registered company Effective | 2023-12-22 | 2024-04-01 | 6 | | 333-239706 | Shelf Effective | 2020-07-06 | 2023-03-02 | 6 | | 333-256614 | Shelf Effective | 2021-05-28 | 2021-06-08 | 2 | | 333-228967 | Shelf Effective | 2018-12-21 | 2020-04-28 | 6 | | 333-217573 | Shelf Effective | 2017-05-01 | 2019-02-07 | 9 | | 333-205001 | IPO Final prospectus | 2015-06-16 | 2016-04-07 | 9 | ## Filings 65 | Filed | Filing | Registration | Accession | | --- | --- | --- | --- | | 2026-10-06 | [424B5](https://www.sec.gov/Archives/edgar/data/1636282/000162828026065249/0001628280-26-065249-index.htm) Shelf takedown | 333-297063 | 0001628280-26-065249 | | 2026-10-05 | [424B5](https://www.sec.gov/Archives/edgar/data/1636282/000162828026064924/0001628280-26-064924-index.htm) Shelf takedown | 333-297063 | 0001628280-26-064924 | | 2026-06-26 | [S-3ASR](https://www.sec.gov/Archives/edgar/data/1636282/000162828026045742/0001628280-26-045742-index.htm) Shelf registered | 333-297063 | 0001628280-26-045742 | | 2026-04-16 | [424B5](https://www.sec.gov/Archives/edgar/data/1636282/000162828026025310/0001628280-26-025310-index.htm) Shelf takedown | 333-293600 | 0001628280-26-025310 | | 2026-04-13 | [424B5](https://www.sec.gov/Archives/edgar/data/1636282/000162828026024940/0001628280-26-024940-index.htm) Shelf takedown | 333-293600 | 0001628280-26-024940 | | 2026-03-04 | [EFFECT](https://www.sec.gov/Archives/edgar/data/1636282/999999999526000722/9999999995-26-000722-index.htm) Declared effective | 333-285341 | 9999999995-26-000722 | | 2026-02-27 | [EFFECT](https://www.sec.gov/Archives/edgar/data/1636282/999999999526000695/9999999995-26-000695-index.htm) Declared effective | 333-293600 | 9999999995-26-000695 | | 2026-02-19 | [S-3](https://www.sec.gov/Archives/edgar/data/1636282/000162828026009814/0001628280-26-009814-index.htm) Shelf registered | 333-293600 | 0001628280-26-009814 | | 2025-10-14 | [424B5](https://www.sec.gov/Archives/edgar/data/1636282/000119312525239143/0001193125-25-239143-index.htm) Shelf takedown | 333-285341 | 0001193125-25-239143 | | 2025-10-14 | [424B5](https://www.sec.gov/Archives/edgar/data/1636282/000119312525237918/0001193125-25-237918-index.htm) Shelf takedown | 333-285341 | 0001193125-25-237918 | | 2025-03-13 | [EFFECT](https://www.sec.gov/Archives/edgar/data/1636282/999999999525000659/9999999995-25-000659-index.htm) Declared effective | 333-281975 | 9999999995-25-000659 | | 2025-03-07 | [EFFECT](https://www.sec.gov/Archives/edgar/data/1636282/999999999525000613/9999999995-25-000613-index.htm) Declared effective | 333-285341 | 9999999995-25-000613 | | 2025-02-27 | [S-3](https://www.sec.gov/Archives/edgar/data/1636282/000162828025008686/0001628280-25-008686-index.htm) Shelf registered | 333-285341 | 0001628280-25-008686 | | 2024-11-19 | [424B5](https://www.sec.gov/Archives/edgar/data/1636282/000162828024048482/0001628280-24-048482-index.htm) Shelf takedown | 333-281975 | 0001628280-24-048482 | | 2024-11-18 | [424B5](https://www.sec.gov/Archives/edgar/data/1636282/000162828024048293/0001628280-24-048293-index.htm) Shelf takedown | 333-281975 | 0001628280-24-048293 | | 2024-10-02 | [EFFECT](https://www.sec.gov/Archives/edgar/data/1636282/999999999524003068/9999999995-24-003068-index.htm) Declared effective | 333-282252 | 9999999995-24-003068 | | 2024-09-20 | [S-3](https://www.sec.gov/Archives/edgar/data/1636282/000162828024041021/0001628280-24-041021-index.htm) Shelf registered | 333-282252 | 0001628280-24-041021 | | 2024-09-18 | [EFFECT](https://www.sec.gov/Archives/edgar/data/1636282/999999999524002887/9999999995-24-002887-index.htm) Declared effective | 333-281975 | 9999999995-24-002887 | | 2024-09-06 | [S-3](https://www.sec.gov/Archives/edgar/data/1636282/000162828024039683/0001628280-24-039683-index.htm) Shelf registered | 333-281975 | 0001628280-24-039683 | | 2024-04-29 | [EFFECT](https://www.sec.gov/Archives/edgar/data/1636282/999999999524001192/9999999995-24-001192-index.htm) Declared effective | 333-278810 | 9999999995-24-001192 | | 2024-04-19 | [S-1](https://www.sec.gov/Archives/edgar/data/1636282/000119312524101185/0001193125-24-101185-index.htm) Registration filed | 333-278810 | 0001193125-24-101185 | | 2024-04-01 | [EFFECT](https://www.sec.gov/Archives/edgar/data/1636282/999999999524000812/9999999995-24-000812-index.htm) Declared effective | 333-276251 | 9999999995-24-000812 | | 2024-04-01 | [EFFECT](https://www.sec.gov/Archives/edgar/data/1636282/999999999524000807/9999999995-24-000807-index.htm) Declared effective | 333-273769 | 9999999995-24-000807 | | 2024-03-27 | [S-1/A](https://www.sec.gov/Archives/edgar/data/1636282/000119312524077777/0001193125-24-077777-index.htm) Amendment | 333-276251 | 0001193125-24-077777 | | 2024-03-14 | [S-1/A](https://www.sec.gov/Archives/edgar/data/1636282/000119312524067885/0001193125-24-067885-index.htm) Amendment | 333-276251 | 0001193125-24-067885 | | 2024-03-01 | [S-1/A](https://www.sec.gov/Archives/edgar/data/1636282/000119312524055961/0001193125-24-055961-index.htm) Amendment | 333-276251 | 0001193125-24-055961 | | 2024-02-05 | [S-1/A](https://www.sec.gov/Archives/edgar/data/1636282/000119312524023071/0001193125-24-023071-index.htm) Amendment | 333-276251 | 0001193125-24-023071 | | 2023-12-22 | [S-1](https://www.sec.gov/Archives/edgar/data/1636282/000119312523302158/0001193125-23-302158-index.htm) Registration filed | 333-276251 | 0001193125-23-302158 | | 2023-11-20 | [EFFECT](https://www.sec.gov/Archives/edgar/data/1636282/999999999523003387/9999999995-23-003387-index.htm) Declared effective | 333-273769 | 9999999995-23-003387 | | 2023-11-15 | [S-1/A](https://www.sec.gov/Archives/edgar/data/1636282/000119312523277992/0001193125-23-277992-index.htm) Amendment | 333-273769 | 0001193125-23-277992 | | 2023-10-10 | [S-1/A](https://www.sec.gov/Archives/edgar/data/1636282/000119312523252528/0001193125-23-252528-index.htm) Amendment | 333-273769 | 0001193125-23-252528 | | 2023-08-07 | [S-3](https://www.sec.gov/Archives/edgar/data/1636282/000119312523205011/0001193125-23-205011-index.htm) Shelf registered | 333-273769 | 0001193125-23-205011 | | 2023-03-02 | [424B5](https://www.sec.gov/Archives/edgar/data/1636282/000119312523057268/0001193125-23-057268-index.htm) Shelf takedown | 333-239706 | 0001193125-23-057268 | | 2022-05-20 | [424B5](https://www.sec.gov/Archives/edgar/data/1636282/000119312522156108/0001193125-22-156108-index.htm) Shelf takedown | 333-239706 | 0001193125-22-156108 | | 2022-05-06 | [424B5](https://www.sec.gov/Archives/edgar/data/1636282/000119312522142966/0001193125-22-142966-index.htm) Shelf takedown | 333-239706 | 0001193125-22-142966 | | 2022-02-09 | [424B5](https://www.sec.gov/Archives/edgar/data/1636282/000119312522032671/0001193125-22-032671-index.htm) Shelf takedown | 333-239706 | 0001193125-22-032671 | | 2021-06-08 | [EFFECT](https://www.sec.gov/Archives/edgar/data/1636282/999999999521002265/9999999995-21-002265-index.htm) Declared effective | 333-256614 | 9999999995-21-002265 | | 2021-05-28 | [S-3](https://www.sec.gov/Archives/edgar/data/1636282/000119312521176929/0001193125-21-176929-index.htm) Shelf registered | 333-256614 | 0001193125-21-176929 | | 2020-07-14 | [EFFECT](https://www.sec.gov/Archives/edgar/data/1636282/999999999520001803/9999999995-20-001803-index.htm) Declared effective | 333-239706 | 9999999995-20-001803 | | 2020-07-06 | [S-3](https://www.sec.gov/Archives/edgar/data/1636282/000119312520187891/0001193125-20-187891-index.htm) Shelf registered | 333-239706 | 0001193125-20-187891 | | 2020-04-28 | [424B5](https://www.sec.gov/Archives/edgar/data/1636282/000119312520123045/0001193125-20-123045-index.htm) Shelf takedown | 333-228967 | 0001193125-20-123045 | | 2020-04-27 | [424B5](https://www.sec.gov/Archives/edgar/data/1636282/000119312520120950/0001193125-20-120950-index.htm) Shelf takedown | 333-228967 | 0001193125-20-120950 | | 2020-04-16 | [424B5](https://www.sec.gov/Archives/edgar/data/1636282/000119312520108746/0001193125-20-108746-index.htm) Shelf takedown | 333-228967 | 0001193125-20-108746 | | 2019-02-13 | [EFFECT](https://www.sec.gov/Archives/edgar/data/1636282/999999999519000212/9999999995-19-000212-index.htm) Declared effective | 333-228967 | 9999999995-19-000212 | | 2019-02-13 | [424B5](https://www.sec.gov/Archives/edgar/data/1636282/000119312519038115/0001193125-19-038115-index.htm) Shelf takedown | 333-228967 | 0001193125-19-038115 | | 2019-02-07 | [424B5](https://www.sec.gov/Archives/edgar/data/1636282/000119312519029933/0001193125-19-029933-index.htm) Shelf takedown | 333-217573 | 0001193125-19-029933 | | 2019-02-05 | [424B5](https://www.sec.gov/Archives/edgar/data/1636282/000119312519028366/0001193125-19-028366-index.htm) Shelf takedown | 333-217573 | 0001193125-19-028366 | | 2018-12-21 | [S-3](https://www.sec.gov/Archives/edgar/data/1636282/000119312518356318/0001193125-18-356318-index.htm) Shelf registered | 333-228967 | 0001193125-18-356318 | | 2018-04-19 | [424B5](https://www.sec.gov/Archives/edgar/data/1636282/000119312518122623/0001193125-18-122623-index.htm) Shelf takedown | 333-217573 | 0001193125-18-122623 | | 2018-04-17 | [424B5](https://www.sec.gov/Archives/edgar/data/1636282/000119312518119782/0001193125-18-119782-index.htm) Shelf takedown | 333-217573 | 0001193125-18-119782 | | 2017-06-06 | [424B5](https://www.sec.gov/Archives/edgar/data/1636282/000119312517195948/0001193125-17-195948-index.htm) Shelf takedown | 333-217573 | 0001193125-17-195948 | | 2017-06-05 | [424B5](https://www.sec.gov/Archives/edgar/data/1636282/000119312517194558/0001193125-17-194558-index.htm) Shelf takedown | 333-217573 | 0001193125-17-194558 | | 2017-05-31 | [424B5](https://www.sec.gov/Archives/edgar/data/1636282/000119312517189241/0001193125-17-189241-index.htm) Shelf takedown | 333-217573 | 0001193125-17-189241 | | 2017-05-30 | [EFFECT](https://www.sec.gov/Archives/edgar/data/1636282/999999999517001401/9999999995-17-001401-index.htm) Declared effective | 333-217573 | 9999999995-17-001401 | | 2017-05-01 | [S-3](https://www.sec.gov/Archives/edgar/data/1636282/000119312517151784/0001193125-17-151784-index.htm) Shelf registered | 333-217573 | 0001193125-17-151784 | | 2016-04-07 | [EFFECT](https://www.sec.gov/Archives/edgar/data/1636282/999999999516004158/9999999995-16-004158-index.htm) Declared effective | 333-205001 | 9999999995-16-004158 | | 2016-04-07 | [424B4](https://www.sec.gov/Archives/edgar/data/1636282/000119312516533048/0001193125-16-533048-index.htm) Final prospectus | 333-205001 | 0001193125-16-533048 | | 2016-04-06 | [EFFECT](https://www.sec.gov/Archives/edgar/data/1636282/999999999516004148/9999999995-16-004148-index.htm) Declared effective | 333-205001 | 9999999995-16-004148 | | 2016-04-06 | [S-1/A](https://www.sec.gov/Archives/edgar/data/1636282/000119312516532240/0001193125-16-532240-index.htm) Amendment | 333-205001 | 0001193125-16-532240 | | 2016-03-28 | [S-1/A](https://www.sec.gov/Archives/edgar/data/1636282/000119312516518824/0001193125-16-518824-index.htm) Amendment | 333-205001 | 0001193125-16-518824 | | 2016-03-14 | [S-1/A](https://www.sec.gov/Archives/edgar/data/1636282/000119312516503657/0001193125-16-503657-index.htm) Amendment | 333-205001 | 0001193125-16-503657 | | 2015-11-05 | [S-1/A](https://www.sec.gov/Archives/edgar/data/1636282/000119312515368322/0001193125-15-368322-index.htm) Amendment | 333-205001 | 0001193125-15-368322 | | 2015-09-14 | [S-1/A](https://www.sec.gov/Archives/edgar/data/1636282/000119312515318935/0001193125-15-318935-index.htm) Amendment | 333-205001 | 0001193125-15-318935 | | 2015-06-16 | [S-1](https://www.sec.gov/Archives/edgar/data/1636282/000119312515224781/0001193125-15-224781-index.htm) Registration filed | 333-205001 | 0001193125-15-224781 | | 2015-05-06 | [DRS](https://www.sec.gov/Archives/edgar/data/1636282/000095012315004987/0000950123-15-004987-index.htm) Draft made public | 377-00998 | 0000950123-15-004987 | [All filings of this company](https://equitycapital.markets/filings?cik=1636282) · [CSV](https://equitycapital.markets/filings.csv?cik=1636282) --- Source page: https://equitycapital.markets/company/1636282 · Data: U.S. SEC EDGAR · CC BY 4.0